Monday, April 29, 2013

Sniffing out schizophrenia

Sniffing out schizophrenia [ Back to EurekAlert! ] Public release date: 29-Apr-2013
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Contact: George Hunka
ghunka@aftau.org
212-742-9070
American Friends of Tel Aviv University

Neurons in the nose could be the key to early, fast, and accurate diagnosis, says a Tel Aviv University researcher

A debilitating mental illness, schizophrenia can be difficult to diagnose. Because physiological evidence confirming the disease can only be gathered from the brain during an autopsy, mental health professionals have had to rely on a battery of psychological evaluations to diagnose their patients.

Now, Dr. Noam Shomron and Prof. Ruth Navon of Tel Aviv University's Sackler Faculty of Medicine, together with PhD student Eyal Mor from Dr. Shomron's lab and Prof. Akira Sawa of Johns Hopkins Hospital in Baltimore, Maryland, have discovered a method for physical diagnosis by collecting tissue from the nose through a simple biopsy. Surprisingly, collecting and sequencing neurons from the nose may lead to "more sure-fire" diagnostic capabilities than ever before, Dr. Shomron says.

This finding, which was reported in the journal Neurobiology of Disease, could not only lead to a more accurate diagnosis, it may also permit the crucial, early detection of the disease, giving rise to vastly improved treatment overall.

From the nose to diagnosis

Until now, biomarkers for schizophrenia had only been found in the neuron cells of the brain, which can't be collected before death. By that point it's obviously too late to do the patient any good, says Dr. Shomron. Instead, psychiatrists depend on psychological evaluations for diagnosis, including interviews with the patient and reports by family and friends.

For a solution to this diagnostic dilemma, the researchers turned to the olfactory system, which includes neurons located on the upper part of the inner nose. Researchers at Johns Hopkins University collected samples of olfactory neurons from patients diagnosed with schizophrenia and a control group of non-affected individuals, then sent them to Dr. Shomron's TAU lab.

Dr. Shomron and his fellow researchers applied a high-throughput technology to these samples, studying the microRNA of the olfactory neurons. Within these molecules, which help to regulate our genetic code, they were able to identify a microRNA which is highly elevated in those with schizophrenia, compared to individuals who do not have the disease.

"We were able to narrow down the microRNA to a differentially expressed set, and from there down to a specific microRNA which is elevated in individuals with the disease compared to healthy individuals," explains Dr. Shomron. Further research revealed that this particular microRNA controls genes associated with the generation of neurons.

In practice, material for biopsy could be collected through a quick and easy outpatient procedure, using a local anesthetic, says Dr. Shomron. And with microRNA profiling results ready in a matter of hours, this method could evolve into a relatively simple and accurate test to diagnose a very complicated illness.

Early detection, early intervention

Though there is much more to investigate, Dr. Shomron has high hopes for this diagnostic method. It's important to determine whether this alteration in microRNA expression begins before schizophrenic symptoms begin to exhibit themselves, or only after the disease fully develops, he says. If this change comes near the beginning of the timeline, it could be invaluable for early diagnostics. This would mean early intervention, better treatment, and possibly even the postponement of symptoms.

If, for example, a person has a family history of schizophrenia, this test could reveal whether they too suffer from the disease. And while such advanced warning doesn't mean a cure is on the horizon, it will help both patient and doctor identify and prepare for the challenges ahead.

###

American Friends of Tel Aviv University supports Israel's leading, most comprehensive and most sought-after center of higher learning. Independently ranked 94th among the world's top universities for the impact of its research, TAU's innovations and discoveries are cited more often by the global scientific community than all but 10 other universities.

Internationally recognized for the scope and groundbreaking nature of its research and scholarship, Tel Aviv University consistently produces work with profound implications for the future.


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Sniffing out schizophrenia [ Back to EurekAlert! ] Public release date: 29-Apr-2013
[ | E-mail | Share Share ]

Contact: George Hunka
ghunka@aftau.org
212-742-9070
American Friends of Tel Aviv University

Neurons in the nose could be the key to early, fast, and accurate diagnosis, says a Tel Aviv University researcher

A debilitating mental illness, schizophrenia can be difficult to diagnose. Because physiological evidence confirming the disease can only be gathered from the brain during an autopsy, mental health professionals have had to rely on a battery of psychological evaluations to diagnose their patients.

Now, Dr. Noam Shomron and Prof. Ruth Navon of Tel Aviv University's Sackler Faculty of Medicine, together with PhD student Eyal Mor from Dr. Shomron's lab and Prof. Akira Sawa of Johns Hopkins Hospital in Baltimore, Maryland, have discovered a method for physical diagnosis by collecting tissue from the nose through a simple biopsy. Surprisingly, collecting and sequencing neurons from the nose may lead to "more sure-fire" diagnostic capabilities than ever before, Dr. Shomron says.

This finding, which was reported in the journal Neurobiology of Disease, could not only lead to a more accurate diagnosis, it may also permit the crucial, early detection of the disease, giving rise to vastly improved treatment overall.

From the nose to diagnosis

Until now, biomarkers for schizophrenia had only been found in the neuron cells of the brain, which can't be collected before death. By that point it's obviously too late to do the patient any good, says Dr. Shomron. Instead, psychiatrists depend on psychological evaluations for diagnosis, including interviews with the patient and reports by family and friends.

For a solution to this diagnostic dilemma, the researchers turned to the olfactory system, which includes neurons located on the upper part of the inner nose. Researchers at Johns Hopkins University collected samples of olfactory neurons from patients diagnosed with schizophrenia and a control group of non-affected individuals, then sent them to Dr. Shomron's TAU lab.

Dr. Shomron and his fellow researchers applied a high-throughput technology to these samples, studying the microRNA of the olfactory neurons. Within these molecules, which help to regulate our genetic code, they were able to identify a microRNA which is highly elevated in those with schizophrenia, compared to individuals who do not have the disease.

"We were able to narrow down the microRNA to a differentially expressed set, and from there down to a specific microRNA which is elevated in individuals with the disease compared to healthy individuals," explains Dr. Shomron. Further research revealed that this particular microRNA controls genes associated with the generation of neurons.

In practice, material for biopsy could be collected through a quick and easy outpatient procedure, using a local anesthetic, says Dr. Shomron. And with microRNA profiling results ready in a matter of hours, this method could evolve into a relatively simple and accurate test to diagnose a very complicated illness.

Early detection, early intervention

Though there is much more to investigate, Dr. Shomron has high hopes for this diagnostic method. It's important to determine whether this alteration in microRNA expression begins before schizophrenic symptoms begin to exhibit themselves, or only after the disease fully develops, he says. If this change comes near the beginning of the timeline, it could be invaluable for early diagnostics. This would mean early intervention, better treatment, and possibly even the postponement of symptoms.

If, for example, a person has a family history of schizophrenia, this test could reveal whether they too suffer from the disease. And while such advanced warning doesn't mean a cure is on the horizon, it will help both patient and doctor identify and prepare for the challenges ahead.

###

American Friends of Tel Aviv University supports Israel's leading, most comprehensive and most sought-after center of higher learning. Independently ranked 94th among the world's top universities for the impact of its research, TAU's innovations and discoveries are cited more often by the global scientific community than all but 10 other universities.

Internationally recognized for the scope and groundbreaking nature of its research and scholarship, Tel Aviv University consistently produces work with profound implications for the future.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-04/afot-sos042913.php

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FAA: Air traffic system soon at full operation

NEW YORK (AP) ? The Federal Aviation Administration said that the U.S. air traffic system will resume normal operations by Sunday evening after lawmakers rushed a bill through Congress allowing the agency to withdraw furloughs of air traffic controllers and other workers.

The FAA said Saturday that it has suspended all employee furloughs and that traffic facilities will begin returning to regular staffing levels over the next 24 hours. The furloughs were fallout from the $85 billion in automatic-across-the-board spending cuts this spring. The bill, passed on Friday, allows the FAA to move as much as $253 million within its budget to areas that will allow it to prevent reduced operations and staffing.

The furloughs started to hit air traffic controllers this past week, causing flight delays that left thousands of travelers frustrated and furious. Planes were forced to take off and land less frequently, so as not to overload the remaining controllers on duty.

The FAA had no choice but to cut $637 million as its share of $85 billion in automatic, government-wide spending cuts that must be achieved by the end of the federal budget year on Sept. 30.

Flight delays piled up across the country Sunday and Monday of this week as the FAA kept planes on the ground because there weren't enough controllers to monitor busy air corridors. Cascading delays held up flights at some of nation's busiest airports, including New York, Baltimore and Washington. Delta Air Lines canceled about 90 flights Monday because of worries about delays. Just about every passenger was rebooked on another Delta flight within a couple of hours. Air travel was smoother Tuesday.

Things could have been worse. A lot of people who had planned to fly this week changed their plans when they heard that air travel might be difficult, according to longtime aviation consultant Daniel Kasper of Compass Lexicon.

"Essentially what happened from an airline's perspective is that people who were going to travel didn't travel," he said. But canceled flights likely led to lost revenue for airlines. Even if they didn't have to incur some of costs of fueling up planes and getting them off the ground, crews that were already scheduled to work still had to paid.

"One week isn't going to kill them, but had it gone on much longer, it would have been a significant hit on their revenues and profits," Kasper said.

It's also a toll on travelers. At New York's LaGuardia airport on Friday, traveler Roger Bentley said "getting on a flight and being delayed really puts people on the spot. It puts people on the edge and makes people edgy and that's not something I want."

The challenges this week probably cost airlines less than disruptions from a typical winter storm, said John F. Thomas, an aviation consultant with L.E.K. Consulting.

"I think the fact that it got resolved this week has minimized the cost as it was more the inconvenience factor," Thomas said.

The budget cuts at the FAA were required under a law enacted two years ago as the government was approaching its debt limit. Democrats were in favor of raising the debt limit without strings attached so as not to provoke an economic crisis, but Republicans insisted on substantial cuts in exchange. The compromise was to require that every government "program, project and activity" ? with some exceptions, like Medicare ? be cut equally.

The FAA had reduced the work schedules of nearly all of its 47,000 employees by one day every two weeks, including 15,000 air traffic controllers, as well as thousands of air traffic supervisors, managers and technicians who keep airport towers and radar facility equipment working. That amounted to a 10 percent cut in hours and pay.

Republicans accused the Obama administration of forcing the furloughs to raise public pressure on Congress to roll back the budget cuts. Critics of the FAA insist the agency could have reduce its budget in other ways that would not have inconvenience travelers including diverting money from other accounts, such as those devoted to research, commercial space transportation and modernization of the air traffic control computers.

President Barack Obama chided lawmakers Saturday over their fix for widespread flight delays, deeming it an irresponsible way to govern, dubbing it a "Band-Aid" and a quick fix, rather than a lasting solution to the spending cuts known as the sequester.

"Republicans claimed victory when the sequester first took effect, and now they've decided it was a bad idea all along," Obama said, singling out the GOP even though the bill passed with overwhelming Democratic support in both chambers.

He scolded lawmakers for helping the Federal Aviation Administration while doing nothing to replace other cuts that he said harm federal employees, unemployed workers and preschoolers in Head Start.

Source: http://news.yahoo.com/faa-air-traffic-system-soon-full-operation-172947164.html

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Obama to appoint Charlotte, N.C. mayor as transportation secretary (cbsnews)

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Sunday, April 28, 2013

Jane Fonda handprints next to Dad's in Hollywood

Jane Fonda is honored with hand and foot prints in cement next to Henry Fonda's outside the Chinese Theater. Jane Fonda will also be present at a special screening of 'On Golden Pond.'

By Sandy Cohen,?Associated Press / April 27, 2013

Actress Jane Fonda arrives at the Oscars at the Dolby Theatre in Los Angeles. The 75-year-old Oscar winner will place her hand and footprints next to her father's in the concrete shrine to celebrity outside Hollywood's TCL Chinese Theatre on Saturday, April 27, 2013.

(Photo by Todd Williamson/Invision/AP, File)

Enlarge

Jane Fonda is planning to shed a few tears on Saturday.

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That's when the 75-year-old Oscar winner will place her hand and footprints next to her father's in the concrete shrine to celebrity outside Hollywood's Chinese Theatre. Then she'll present a special screening of the film she made with her dad, 1981's "On Golden Pond." The cement and cinematic tribute is part of the 2013 TCM Classic Film Festival, which is honoring Jane Fonda.

"I am very, very excited," Fonda said in an interview this week. "I thought probably I would die and this would never happen. I'm just really thrilled that it actually is happening and not only that, but I get to put my hand and footprints right next to my father. ... I'm just so happy I'll probably cry."

The honor inspired Fonda to reflect on her career, which hasn't slowed since she returned to acting in 2005 after a 15-year hiatus.

"I've made some really good films. There's also a lot of films I wish I could do over again," she said. "But I've been lucky: I've worked with some great directors, and I feel like I'm still a work in progress as an actor. I feel like I'm still learning."

After her guest-starring stint on "The Newsroom," she's more interested than ever in television.

"I'd love to have a television series of my own," Fonda said. "I'm hoping that might happen."

A fitness pioneer, Fonda continues to focus on health and wellness with a series of videos aimed at older exercisers. She also inspired countless Oscar watchers earlier this year with her fitted, bright yellow gown, and she serves as L'Oreal's oldest spokeswoman.

"When you're younger, you don't have to put so much time into it, but also I didn't care that much. I was an activist and I didn't think so much about how I appeared," she said. "As I've gotten older, I've paid more attention to how I dress, how I look, what makeup I use, what skincare products I use... I guess one reason that I put more effort into looking good now is because I think it gives hope to other women. It takes the edge off the fear that young people have of getting older."

The wisdom and openness that come with aging are easy to wear well, and Fonda said she's happier now than ever.

"This event that's coming up where I get to put my hand and shoeprints next to my dad in front of the Chinese Theatre, it's coming at a very happy time in my life," Fonda said, "and making it even happier."

___

Follow AP Entertainment Writer Sandy Cohen on Twitter: www.twitter.com/APSandy.

___

Copyright 2013 The Associated Press.

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/csXCNpFN35g/Jane-Fonda-handprints-next-to-Dad-s-in-Hollywood

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Saturday, April 27, 2013

American Idol Results: Four No More?

Source: http://www.thehollywoodgossip.com/2013/04/american-idol-results-four-no-more/

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Rethinking early atmospheric oxygen

Thursday, April 25, 2013

A research team of biogeochemists at the University of California, Riverside has provided a new view on the relationship between the earliest accumulation of oxygen in the atmosphere, arguably the most important biological event in Earth history, and its relationship to the sulfur cycle.

A general consensus exists that appreciable oxygen first accumulated in Earth's atmosphere around 2.4 to 2.3 billion years ago. Though this paradigm is built upon a wide range of geological and geochemical observations, the famous "smoking gun" for what has come to be known as the "Great Oxidation Event" (GOE) comes from the disappearance of anomalous fractionations in rare sulfur isotopes.

"These isotope fractionations, often referred to as 'mass-independent fractionations,' or 'MIF' signals, require both the destruction of sulfur dioxide by ultraviolet energy from the sun in an atmosphere without ozone and very low atmospheric oxygen levels in order to be transported and deposited in marine sediments," said Christopher T. Reinhard, the lead author of the research paper and a former UC Riverside graduate student. "As a result, their presence in ancient rocks is interpreted to reflect vanishingly low atmospheric oxygen levels continuously for the first ~2 billion years of Earth's history."

However, diverse types of data are emerging that point to the presence of atmospheric oxygen, and, by inference, the early emergence of oxygenic photosynthesis hundreds of millions of years before these MIF signals disappear from the rock record. These observations motivated Reinhard and colleagues to explore the possible conditions under which inherited MIF signatures may have persisted in the rock record long after oxygen accumulated in the atmosphere.

Using a simple quantitative model describing how sulfur and its isotopes cycle through the Earth's crust, the researchers discovered that under certain conditions these MIF signatures can persist within the ocean and marine sediments long after O2 increases in the atmosphere. Simply put, the weathering of rocks on the continents can transfer the MIF signal to the oceans and their sediments long after production of this fingerprint has ceased in an oxygenated atmosphere.

"This lag would blur our ability to date the timing of the GOE and would allow for dynamic rising and falling oxygen levels during a protracted transition from an atmosphere without oxygen to one rich in this life-giving gas," Reinhard said.

Study results appear in Nature's advanced online publication on April 24.

Reinhard explained that once MIF signals formed in an oxygen-poor atmosphere are captured in pyrite and other minerals in sedimentary rocks, they are recycled when those rocks are later uplifted as mountain ranges and the pyrite is oxidized.

"Under certain conditions, this will create a sort of 'memory effect' of these MIF signatures, providing a decoupling in time between the burial of MIF in sediments and oxygen accumulation at Earth's surface," he said.

According to the researchers, the key here is burying a distinct MIF signal in deep sea sediments, which are then subducted and removed from Earth's surface.

"This would create a complementary signal in minerals that are weathered and delivered to the oceans, something that we actually see evidence of in the rock record," said Noah Planavsky, the second author of the research paper and a former UC Riverside graduate student now at Caltech. "This signal can then be perpetuated through time without the need to generate it within the atmosphere contemporaneously."

Reinhard, now a postdoctoral fellow at Caltech and soon to be an assistant professor at Georgia Institute of Technology, explained that although the researchers' new model provides a plausible mechanism for reconciling recent conflicting data, this can only occur when certain key conditions are met ? and these conditions are likely to have changed through time during Earth's long early history.

"There is obviously much further work to do, but we hope that our model is one step toward a more integrated view of how Earth's crust, mantle and atmosphere interact in the global sulfur cycle," he said.

Timothy W. Lyons, a professor of biogeochemistry at UCR and the principal investigator of the research project noted that this is a fundamentally new and potentially very important way of looking at the sulfur isotope record and its relationship to biospheric oxygenation.

"The message is that sulfur isotope records, when viewed through the filter of sedimentary recycling, may challenge efforts to precisely date the GOE and its relationship to early life, while opening the door to the wonderful unknowns we should expect and embrace," he said.

###

University of California - Riverside: http://www.ucr.edu

Thanks to University of California - Riverside for this article.

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Source: http://www.labspaces.net/127923/Rethinking_early_atmospheric_oxygen

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Congressman questions legal handling of Boston suspect

By Tabassum Zakaria

WASHINGTON (Reuters) - U.S. House Intelligence Committee Chairman Mike Rogers has expressed concern to Attorney General Eric Holder that the legal handling of the Boston Marathon bombing suspect may have "prematurely cut off" a lawful FBI interview.

Rogers, a Republican from Michigan, said he wanted more information about the appearance by U.S. Magistrate Judge Marianne Bowler at the hospital where Dzhokhar Tsarnaev is being held after being charged in the bombings that killed three people and wounded more than 200.

"Specifically, I would like more information as to who determined that the proceedings would occur at that specific time and place while questioning was still ongoing," Rogers said in a letter dated Wednesday and obtained by Reuters on Thursday.

"My understanding is that the normal practice places the duty to take the defendant to court (and accordingly discretion as to timing consistent with the rules) on law enforcement, and not the court," the letter said.

Tsarnaev, who was captured on Friday, was charged at a bedside hearing on Monday with using a weapon of mass destruction and malicious destruction of property resulting in death. He and his older brother, Tamerlan, who was killed in a shootout with police, are both suspected with carrying out the Boston Marathon bombings.

It was during the proceeding before Bowler that Tsarnaev was warned of his right to remain silent and his right to an attorney.

Before Monday's hearing, Dzhokhar Tsarnaev told investigators that he and his brother had also planned to set off bombs in New York's Times Square, according to Police Commissioner Ray Kelly.

There is an ongoing debate about whether authorities should hold off reading the so-called Miranda warning to a suspect in a terrorism case until questioning has been completed to ensure no other plot is in the works that could harm the public.

A federal law enforcement official told Reuters that the magistrate judge initiated the process.

"The court schedules initial court appearances for defendants, not the Justice Department," the official said.

Federal Rules of Criminal Procedure require that anyone who is arrested must appear before a magistrate judge "without unnecessary delay" and that, during the proceeding, the magistrate judge must advise the defendant of his or her right to remain silent.

After the criminal complaint was filed on Sunday, Bowler sought to arrange an appearance for Monday morning, according to the law enforcement official. Prosecutors, the federal public defender and FBI agents in Boston were all aware of Bowler's plans, the official said.

(Additional reporting by Lawrence Hurley; editing by Karey Van Hall and Christopher Wilson)

Source: http://news.yahoo.com/congressman-questions-legal-handling-boston-suspect-231858887.html

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Living with Google Glass, Day Two: Around the House

"You look ridiculous." This was not exactly the reaction I was hoping to receive from my wife the first time she saw me wearing Glass. She was long-since asleep when I arrived late the night before, and so had missed my triumphant, technologically augmented homecoming. I confess Google Glass is a bit odd-looking, but my wife is even more of a hardcore Trekker than I am and I thought somehow this headgear would channel her deep-seated love for bizarre, high-tech facial appendages.

Nope. She wasn't the least bit impressed. When she tried them later, she came around a bit, but spent more time saying the silicon grippers pinched her nose than reveling in the potential future applications of such technology. You can't please everybody.

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Source: http://www.engadget.com/2013/04/26/living-with-google-glass-day-two/?utm_medium=feed&utm_source=Feed_Classic&utm_campaign=Engadget

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Top Samsung Galaxy S4 forum threads

Samsung Galaxy S4

As devices start to make their way into more hands, the forums are jumping with discussion

There's been more news about the Samsung Galaxy S4 than you can shake a stick at as of late, and that means two things. Firstly, it's time for them to start trickling in from preorders and more people have them. The second is that people want to talk about it. That's where oru forums come into play. You can talk as much Galaxy S4 as you want with people just like you and me, who can't get enough and are excited. Take a look at a few.

So have look at our review, then head into the forums and see what all the fuss is about!

    


Source: http://feedproxy.google.com/~r/androidcentral/~3/mDYRAjfKHb0/story01.htm

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Friday, April 26, 2013

Yahoo snags exclusive rights to Saturday Night Live's archives starting September 1st

Yahoo snags exclusive rights to Saturday Night Live's archives starting September 1st

Yahoo may have failed in its bid to acquire Hulu last year, but CEO Marissa Mayer announced it's snagged rights to show something the streaming site has been known for: Saturday Night Live. The deal with Broadway Video will give Yahoo exclusive online access to archived SNL content from 1975 through 2013 including show clips, "select" musical performances, behind the scenes and dress rehearsal clips. Yahoo will also have non-exclusive access to show current season Saturday Night Live clips in the US and a license to distribute library show clips internationally. Beginning September 1st, those archived clips will be pulled from other internet video platforms (presumably Hulu and Netflix) for one year. The press release (included after the break) indicates Broadway and Yahoo will celebrate the partnership at Yahoo!'s Digital Content NewFront event on the 29th. We'll see if there's more to learn about Yahoo's ever-evolving media strategy then.

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Source: Yahoo! Yodel, Marissa Mayer (Twitter)

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/ri_0owj3n58/

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Moms more likely than other employees to leave male-dominated jobs with long hours

Apr. 23, 2013 ? As demands for long work hours continue to increase, an Indiana University study found that mothers are more likely than other employees to leave jobs in male-dominated fields. This trend was not seen in balanced or female-dominated occupations.

"Mothers were 52 percent more likely than other women to leave their jobs if they were working a 50-hour week or more, but only in occupations dominated by men," said Youngjoo Cha, assistant professor in the Department of Sociology at IU Bloomington. "Many of these are lucrative fields, such as law, medicine, finance and engineering."

Her findings, published in the journal Gender & Society, reveal how overwork contributes to occupational segregation and stalled efforts to narrow the gender gap in white-collar workplaces. Many of the mothers who leave these jobs exit the job market entirely because of the lack of suitable part-time positions in these fields.

The study analyzed data collected from the Survey of Income and Program Participation, a national longitudinal household survey, conducted by the U.S. Census Bureau. It included 382 occupations, 173 of which were considered male-dominated, where men made up 70 percent or more of the workforce.

Cha said workplaces dominated by men tend to operate on outdated assumptions about "separate spheres" marriage -- families with a homemaking woman and a breadwinning man. Yet today, both partners are employed in nearly 80 percent of American couples.

Here are more findings from "Overwork and the Persistence of Gender Segregation in Occupations:

  • In male-dominated occupations, overwork was more likely than in balanced fields or female-dominated fields.
  • Mothers in male-dominated occupations were more discouraged despite the fact that the women who survived in those more masculine fields may on average be more committed to work than overworking women in other jobs.
  • Higher education levels make it more likely that women stay in their jobs, but not enough to overcome the discouraging effect of being an overworking mother.
  • Meanwhile, men (whether fathers or not) and women without children were not more likely to leave their jobs in overworking fields.
  • When mothers left their jobs, some moved to less male-dominated professions; others entirely left the labor force.

Cha advocates labor policies that can reduce work-family conflicts and benefit women, men, families and firms. In her article, she recommends promoting workplace policies that minimize the expectation for overwork, such as setting the maximum allowable work hours, prohibiting compulsory overtime, expanding the coverage of the Fair Labor Standards Act's overtime provisions, and granting employees the right to work part-time hours without losing benefits.

More than one-third of men and nearly one-fifth of women in professions work more than 50 hours a week. While men and women have adjusted their ability to share domestic caregiving in recent years, these more extreme situations of overwork demonstrate the limits of the flexibility that men and women often aim for but can't always achieve.

Cha has found in her earlier research that when husbands overwork, it limits their contributions to home responsibilities and restricts the wife's time for work outside the home. When the wife overworks, according to her research, it rarely affects the husband's work.

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The above story is reprinted from materials provided by Indiana University, via EurekAlert!, a service of AAAS.

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Journal Reference:

  1. Y. Cha. Overwork and the Persistence of Gender Segregation in Occupations. Gender & Society, 2013; 27 (2): 158 DOI: 10.1177/0891243212470510

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/living_well/~3/je-O4bUQYfk/130424103136.htm

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Thursday, April 25, 2013

3 Doors Down bassist enters rehab following arrest

A?photo released by the Metropolitan Nashville Police Department is Robert Todd Harrell. Harrell, bassist with the rock band 3 Doors Down has been charged with vehicular homicide by intoxication after an interstate crash claimed the life of another motorist Sunday April 21, 2013, in the Nashville area, police said. (AP Photo/Metropolitan Nashville Police Department)

A?photo released by the Metropolitan Nashville Police Department is Robert Todd Harrell. Harrell, bassist with the rock band 3 Doors Down has been charged with vehicular homicide by intoxication after an interstate crash claimed the life of another motorist Sunday April 21, 2013, in the Nashville area, police said. (AP Photo/Metropolitan Nashville Police Department)

(AP) ? An attorney says 3 Doors Down bassist Robert Todd Harrell has checked himself into drug treatment after being charged with killing someone while driving under the influence.

Attorney Ed Ryan says he could not disclose where Harrell is being treated.

Harrell is facing multiple charges, including vehicular homicide by intoxication. Authorities say he caused a fatal interstate crash in a Nashville suburb last weekend. Records show authorities discovered that Harrell had numerous narcotics on him while he was being processed into the Nashville jail.

Police say the 41-year-old bassist was speeding down Interstate 40 in his Cadillac CTS when he clipped the back of a pickup truck, causing a crash that killed the driver of the truck.

The bassist is due in court next month and is free on bond.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/4e67281c3f754d0696fbfdee0f3f1469/Article_2013-04-24-3%20Doors%20Down%20Bassist/id-220263f086f3445085c69e5e7c94fdbf

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Hyatt House Pittsburgh-South Side Celebrates ... - Franchising.com

The 136-room Hyatt House hotel is located in Pittsburgh?s South Side

CHICAGO - April 24, 2013 - (BUSINESS WIRE) -?Hyatt Hotels Corporation (NYSE: H), Concord Hospitality Enterprises, and Oxford Development Company today announce the opening of Hyatt house Pittsburgh-South Side, the first Hyatt house hotel in the city of Pittsburgh.

?We are excited to bring Hyatt house to this vibrant neighborhood. Hyatt house is everything the name represents ? a welcoming and warm environment that encourages guests to live like residents,? said Michael Rhoten, general manager, Hyatt house Pittsburgh-South Side. ?We want each and every guest who comes through our doors to feel that they can let their real-life routines roll on, even when they?re on the road.?

Hyatt house Pittsburgh-South Side is situated in Pittsburgh?s SouthSide Works shopping, dining and entertainment district. Located near some of the region?s top corporate headquarters, such as American Eagle, Thermo Fisher Scientific and Level 3 Communications, the hotel will be an ideal spot for business travelers and those on extended corporate travel.

Additionally, Hyatt house Pittsburgh-South Side is just minutes from University of Pittsburgh?s main campus in Oakland, as well as Carnegie Mellon University and the world-renowned UPMC hospitals. Downtown Pittsburgh and the North Shore are just a few miles away, where travelers will find CONSOL Energy Center, Heinz Field, PNC Park, and the Cultural District.

?Concord currently operates 13 hotels in the Greater Pittsburgh area, and Hyatt house Pittsburgh South-Side is the perfect addition to our Pittsburgh portfolio,? said Mark Laport, president, Concord Hospitality Enterprises. ?The Hyatt house brand and South Side location both align with our emphasis on quality, integrity and contributing to the communities in which we operate.?

The opening of Hyatt house Pittsburgh-South Side marks the first Hyatt-branded hotel opened by Oxford Development Company in Western Pennsylvania and the third Hyatt-branded hotel opened by Oxford in the past four years.

?We at Oxford are very pleased to be expanding our relationship with Hyatt and to once again be co-investing with and entrusting the hotel?s operations to Concord,? said Steve Guy, president and chief executive officer, Oxford Development Company. ?We are excited to bring to our home town the dedication to high standards and the devotion to guest services that Hyatt, Concord and Oxford represent.?

Hyatt house Pittsburgh-South Side offers:

  • 136 residentially inspired upscale studio, one- and two-bedroom kitchen suites
  • Kitchen suites will feature a full kitchen, living space and bedroom
  • Free Wi-Fi access and remote printing throughout the hotel
  • Complimentary full hot breakfast served daily, featuring made-to-order omelets and other rotating savory options like bacon, sausage, French Toast, waffles and more
  • H BAR featuring the brand?s Sip+Savor Menu ? a delicious menu of home-cooked comforts and full bar
  • More than 1,500 square feet of flexible, high-tech meeting/function space for business or social gatherings
  • Range of public spaces, including a 24-hour workout room & guest laundry facilities in addition to an indoor pool and a 6,000-square-foot outdoor patio with a fire pit and gas grills
  • 24/7 Guest Market, plus a complimentary grocery shopping available to the extended stay traveler
  • A pet-friendly policy that welcomes dogs or cats
  • Connection to the South Shore Riverfront Trail

Hyatt House Pittsburgh South Side Leadership

Hyatt house Pittsburgh-South Side is under the leadership of General Manager Michael Rhoten and Director of Sales Danielle Phillips. In his role, Rhoten is directly responsible for managing the day-to-day operations of the hotel, including overseeing the hotel?s more than 30 associates and ensuring guests encounter the purposeful service for which Hyatt house is known. Rhoten is joined by Phillips, director of sales, who is responsible for providing sales service and support to travelers and meeting planners frequenting the Pittsburgh area.

About?Hyatt house

Launched in 2012, Hyatt house was designed to welcome residents rather than guests. Inspired by extensive research of guest experiences, Hyatt house is designed to surprise and delight with services, amenities, upscale spaces and a casual, comfortable environment that will remind guests of home. Residentially inspired studio, one- and two-bedroom suites feature contemporary full kitchens, living space with flat panel HDTVs and bedrooms with a plush bed. Complimentary Wi-Fi is available throughout the hotel. A complimentary full hot breakfast is served daily as well as a complimentary Evening Social with savory bites, beer and wine. Some locations have an H BAR featuring the Sip+Savor menu and full bar. Public spaces include a 24-hour workout room, Guest Market and laundry facilities. A friendly House Host is available to check a guest in, provide directions or help with other needs to help the guest feel at home. All of which contribute to allowing guests to keep their real-life routines rolling while on the road. Hyatt house was recently named one of the 10 Best Hotel Chains for Families by Parents Magazine. Chosen amongst more than 70 hotels chains, Hyatt house was recognized for its convenient, functional, and family-friendly amenities, with separate parent and child sleeping areas topping the list.

Hyatt house, a brand of Hyatt Hotels Corporation, offers more than 50 locations throughout the United States. To learn more about Hyatt house or to book a reservation, visit http://www.Hyatthouse.com or call 866-XS-Hyatt (866-974-9288).

About Concord Hospitality Enterprises

Concord Hospitality Enterprises Company, an award-winning hotel management and development company based in Raleigh, N.C., manages 90 upscale select-service and full-service hotels offering more than 12,000 guest rooms in 24 states and two Canadian provinces. The company operates hotels and resorts under such well-known industry elite brands as Marriott, Hilton, Hyatt, Starwood, and Choice Hotels, as well as select independent boutique hotels. Formed in 1985, Concord is routinely listed among the nation?s top management companies and recently won some of the industry?s top honors from Marriott International and Hyatt. Concord properties are some of the most awarded hotels in the country, having won nearly 100 top honors in the past two years. For more information, visit www.concordhotels.com.

About Oxford Development Company

Based in Pittsburgh, Oxford Development Company is the largest privately owned real estate services firm in Western Pennsylvania. With 50 years of experience in the local, regional and national marketplace, Oxford provides a full range of real estate services, including real estate development, project and construction management, property management, brokerage and investment advisory services. Oxford is committed to making the built environment more sustainable and has been involved in the creation of over 4.3 million square feet of LEED certified projects throughout the country, including the CONSOL Energy Center, the first LEED Gold NHL arena in the world. Visit us online at www.oxforddevelopmentcompany.com.

About Hyatt Hotels Corporation

Hyatt Hotels Corporation, headquartered in Chicago, is a leading global hospitality company with a proud heritage of making guests feel more than welcome. Thousands of members of the Hyatt family strive to make a difference in the lives of the guests they encounter every day by providing authentic hospitality. The Company?s subsidiaries manage, franchise, own and develop hotels and resorts under the Hyatt?, Park Hyatt?, Andaz?, Grand Hyatt?, Hyatt Regency?, Hyatt Place? and Hyatt HouseTM brand names and have locations on six continents. Hyatt Residential Group, Inc., a Hyatt Hotels Corporation subsidiary, develops, operates, markets or licenses Hyatt ResidencesTM and Hyatt Residence ClubTM. As of December 31, 2012, the Company?s worldwide portfolio consisted of 500 properties in 46 countries. For more information, please visit www.Hyatt.com.

Contact:

Hyatt Hotels & Resorts
Stephanie Sheppard
(312) 780-5399
Stephanie.sheppard@Hyatt.com

###

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Source: http://www.franchising.com/news/20130424_hyatt_house_pittsburghsouth_side_celebrates_offici.html

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Significant step forward in combating antibiotic resistance

Apr. 24, 2013 ? Antibiotic resistance is a global problem. The World Health Organisation (WHO) estimates that for tuberculosis alone multi-drug resistance accounts for more than 150,000 deaths each year. WHO warns of "a doomsday scenario of a world without antibiotics," in which antibiotic resistance will turn common infections into incurable killers and make routine surgeries a high-risk gamble.

Certain types of bacteria are a scourge of the hospital environment because they are extremely resistant to antibiotics and consequently difficult, if not impossible, to treat. This group of bacteria is classified as 'gram-negative' because their cells have a double membrane or outer layer, compared with gram-positive bacteria, which just have one outer layer.

Not only are these cells difficult to penetrate in the first instance, due to their double membrane, but they have effective 'pumps' which quickly reject anything that interferes with the activity of protein-building within the cell and the development of the protective cell wall.

This research, which was funded by the Wellcome Trust, gives for the first time a clear insight into how these protein components of the pump work together to transport an antibiotic from the cell.

Examples of gram-negative bacteria include those which cause food poisoning, meningitis, gonorrhoea and respiratory problems. Since the antibiotic is an interfering agent, many of these pathogenic bacteria use the membrane pumps to transport the medication out of the cell.

The pumps are made up of three different proteins within the cell that work together to bring about the movement. Research lead, Professor Adrian Walmsley from Durham University's School of Biological and Biomedical Sciences explained:

"Patients with bacterial infections are often treated with antibiotics, but since many strains are resistant to one or more of these drugs, clinicians often try to bring such infections under control by prescribing a combination of different types of antibiotics in the hope that they will override the resistance mechanisms. This sometimes works, but other times it does not. Pumps exacerbate this situation by reducing the effective concentration of the drug inside the cell. "

"By investigating how these pumps function, we have been able to identify the molecular events that are involved in binding and transporting an antibiotic from the cell. This advance in our understanding will ultimately aid the development of 'pump blockers'. This is important because these pumps often confer resistance to multiple, structurally unrelated, drugs; which means that they could also be resistant to new drugs which have never been used before."

Dr Vassiliy Bavro from the the Institute of Microbiology and Infection at the University of Birmingham said: "This study greatly expands our understanding of the mechanistic aspects of the pump function, and in particular challenges our previous concepts of energy requirements for pump assembly and cycling. By elucidating the intricate details of how these essential nanomachines come together, it also provides a new working model of their functional cycle in general, paving the way to development of novel approaches to disrupting their function."

Dr Ted Bianco, Acting Director of the Wellcome Trust, said: "A world without antibiotics is a world where simple surgery becomes a life-threatening procedure, where a scratch from a rose might prove fatal, and where diseases like tuberculosis return with a ferocity not seen in Britain since the Victorian era. This is why fundamental research to understand the mechanisms of antibiotic resistance is so important. Only when we know what we're up against can researchers begin to design new antibacterial agents to help us win the war against bacterial infections."

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Story Source:

The above story is reprinted from materials provided by Durham University.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Thamarai K. Janganan, Vassiliy N. Bavro, Li Zhang, Maria In?s Borges-Walmsley, Adrian R. Walmsley. Tripartite efflux pumps: energy is required for dissociation, but not assembly or opening of the outer membrane channel of the pump. Molecular Microbiology, 2013; 88 (3): 590 DOI: 10.1111/mmi.12211

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/9lrScfLULdA/130424222554.htm

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FlipSide Blog | Kids and teens invited to regional 'Wicked' workshop ...

A Class Act NY, a Manhattan acting studio for kids and teens, will bring its programs to the area June 2. In conjunction with the Jewish Federation of Greater Harrisburg, Class Act will offer a Wicked Workshop 1 to 5 p.m. with Broadway actor Ben Cameron and a music director. The JCC is at 3301 N. Front St., Harrisburg.

Budding thespians of all skill levels, ages 7 to 16, will learn a song and dance combination and work on a scene. Participants will be divided by age group and can perform an audition song for Cameron and the music director. During a snack break, Cameron will answer kids questions and sign autographs.

Cost is $150 to $175. Space is limited. For details and to register, call 717-236-9555 or visit www.jewishharrisburg.org. For details about ?Wicked,? visit www.wickedthemusical.com.

YSO to host My Opus Magnum summer music camp:
The York Symphony Orchestra will hold its annual Summer Music Camp, My Opus Magnum, 9 a.m. to noon July 22 to 26 at Logos Academy, 250 W. King St., York. The camp will offer youth musicians in grades 3 through 12 the opportunity to learn the steps of creating a song, preparing sheet music and filling out the necessary forms to copyright the material. The camp includes individual coaching using computer software and keyboards. The new head instructor, Chris Whittaker, is a conductor, composer and pianist from York, who now lives in New York City. Cost is $95 per student. A downloadable application can be found at www.yorksymphony.org or by calling 717-812-0717.

I'm a FlipSide reporter covering all things entertainment in the White Rose City and beyond. Contact me at emccracken@ydr.com or leave a comment.

Source: http://www.yorkblog.com/flipside/2013/04/24/kids-and-teens-invited-to-regional-wicked-workshop-june-2-in-harrisburg/

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Hunting That Elusive Tea Party Bomber (Powerlineblog)

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Wednesday, April 24, 2013

Ricin suspect hearing cancelled, announcement set

Federal agents wearing hazardous material suits and breathing apparatus inspect the home and possessions in the West Hills Subdivision house of Paul Kevin Curtis in Corinth, Miss., Friday, April 19, 2013. Curtis is in custody under the suspicion of sending letters covered in ricin to the U.S. President Barack Obama and U.S. Sen. Roger Wicker, R-Miss. (AP Photo/Rogelio V. Solis)

Federal agents wearing hazardous material suits and breathing apparatus inspect the home and possessions in the West Hills Subdivision house of Paul Kevin Curtis in Corinth, Miss., Friday, April 19, 2013. Curtis is in custody under the suspicion of sending letters covered in ricin to the U.S. President Barack Obama and U.S. Sen. Roger Wicker, R-Miss. (AP Photo/Rogelio V. Solis)

Jack Curtis, brother of Paul Kevin Curtis, speaks outside of federal court in Oxford, Miss. on Monday, April 22, 2013. Paul Kevin Curtis is in custody under the suspicion of sending letters which tested positive for ricin to U.S. President Barack Obama and U.S. Sen. Roger Wicker, R-Miss. (AP Photo/Oxford Eagle, Bruce Newman) NO SALES

OXFORD, Miss. (AP) ? Officials cancelled a hearing on Tuesday for the Mississippi man accused of mailing poisoned letters to President Barack Obama, a U.S. senator and a local judge, and a news conference was planned for the afternoon.

Federal authorities and defense attorneys will speak to reporters at 5 p.m. CDT about the case, said Christi McCoy, the defense attorney for suspect Paul Kevin Curtis. The reason for the change in plans wasn't immediately clear.

The announcement came 90 minutes after the third day of the detention and preliminary hearing was supposed to start in federal court. Lawyers spent that time conferring with the judge. Later, Curtis and family members were escorted into a meeting room with his lawyers, followed by a probation officer.

FBI spokeswoman Deborah Madden referred questions to the U.S. attorney's office.

On Monday, FBI Agent Brandon Grant testified that Friday searches of Curtis' vehicle and house in Corinth, Miss., found no ricin, ingredients for the poison, or devices used to make it. A search of Curtis' computers found no evidence he researched making ricin.

"There was no apparent ricin, castor beans or any material there that could be used for the manufacturing, like a blender or something," Grant testified. He speculated that Curtis could have thrown away the processor.

Through McCoy, Curtis has denied involvement in letters containing ricin sent to Obama, Mississippi Republican Sen. Roger Wicker, and a Lee County, Miss., judge. The first of the letters was found April 15.

"The searches are concluded, not one single shred of evidence was found to indicate Kevin could have done this," McCoy told reporters after the hearing Monday.

McCoy also questioned why Curtis would have signed the letters "I am KC and I approve this message," a phrase he had used on his Facebook page.

McCoy said in court that someone may have framed Curtis, suggesting that a former business associate of Curtis' brother, a man with whom Curtis had an extended exchange of angry emails, may have set him up.

Still, Grant testified that authorities believe they have the right suspect.

"Given the right mindset and the Internet and the acquisition of material, other people could be involved. However, given information right now, we believe we have the right individual," he said.

Grant said lab analysis shows the poison in the letters was in a crude form that could have been created by grinding castor beans in a food processor or coffee grinder.

Grant testified Friday that authorities tried to track down the sender of the letters by using a list of Wicker's constituents with the initials KC, the same initials in the letters. Grant said the list was whittled from thousands to about 100 when investigators isolated the ones who lived in an area that would have a Memphis, Tenn., postmark, which includes many places in north Mississippi. He said Wicker's staff recognized Curtis as someone who had written the senator before.

All the envelopes and stamps were self-adhesive, Grant said Monday, meaning they won't yield DNA evidence. He said thus far the envelopes and letters haven't yielded any fingerprints.

___

Follow Jeff Amy at http://twitter.com/jeffamy.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2013-04-23-US-Suspicious-Letters/id-09dcf5373a3a4fee985219a25d42c92d

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Sweeteeth Chocolates - Cool Hunting

sweeteeth-chocolate-1.jpg

Admittedly, we were first seduced by Sweeteeth's irreverent packaging for their "Call of the Wild" port wine caramel chocolate bar, but once unwrapped it became immediately clear that the contents inside were also worth a healthy drool. While "Call of the Wild" oozes with sticky sweet caramel for an indulgence that is best shared (and may inspire a little mating of your own), the other two bars we tried from John Eric Battles?the Charleston, SC-based chocolatier behind Sweeteeth?downplays the sugar in favor of spicier concoctions. "Cinnapsis" is a crunchy blend of dark milk chocolate, dried apples, candied pecans and cinnamon, while "PB+C" combines dark and milk chocolate for the silky shell, which is filled with natural peanut butter, cocoa butter and chipotle peppers, and is topped off with pink Himalayan sea salt.

sweeteeth-chocolate-22.jpg

Sweeteeth bars are handmade in small batches to keep flavor at the forefront of their operation. Chocolates span $5-7 and can be found online from their shop or from NY Mouth.

Images by Karen Day

Source: http://www.coolhunting.com/food-drink/sweeteeth-chocolates.php

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Video: Bucs GM explains the process of the Revis trade

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Senate DFLers want to raise income taxes for wider group, tax clothing (Star Tribune)

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